.rte-specialty{--teal:#145d69;--teal2:#1d7682;--soft:#edf7f8;--line:#c9dfe2;--ink:#17343b;--muted:#5d7379;max-width:1180px;margin:0 auto;color:var(--ink);font:15px/1.5 system-ui,-apple-system,BlinkMacSystemFont,"Segoe UI",sans-serif}
.rte-specialty *{box-sizing:border-box}.rte-specialty a{color:#145f70}.rte-specialty__head{display:flex;gap:16px;justify-content:space-between;align-items:flex-start;border-bottom:2px solid var(--line);padding:0 0 14px;margin-bottom:16px}.rte-specialty h1{margin:0;font-size:clamp(25px,3vw,38px);letter-spacing:-.025em}.rte-specialty__sub{margin:4px 0 0;color:var(--muted);max-width:760px}.rte-specialty__badge{white-space:nowrap;border:1px solid var(--line);border-radius:999px;padding:5px 9px;font-size:12px;color:var(--teal);background:#fff}.rte-specialty__toolbar{display:flex;gap:8px;flex-wrap:wrap;align-items:center;margin:12px 0 18px}.rte-specialty__search{flex:1;min-width:220px;border:1px solid #aacbd0;border-radius:7px;padding:9px 11px;font:inherit}.rte-specialty__filter{border:1px solid var(--line);background:#fff;color:var(--ink);border-radius:999px;padding:7px 10px;cursor:pointer}.rte-specialty__filter[aria-pressed=true]{background:var(--teal);color:#fff;border-color:var(--teal)}.rte-specialty__intro{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:10px;margin:0 0 18px}.rte-specialty__intro>div{border:1px solid var(--line);border-radius:9px;padding:11px;background:linear-gradient(180deg,#fff,var(--soft))}.rte-specialty__intro strong{display:block;margin-bottom:3px}.rte-specialty__grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:12px}.rte-specialty__card{border:1px solid var(--line);border-radius:10px;background:#fff;padding:14px;min-width:0}.rte-specialty__card[hidden]{display:none}.rte-specialty__card h2{font-size:17px;margin:0 0 4px;color:#104d58}.rte-specialty__meta{font-size:11px;color:var(--teal2);text-transform:uppercase;letter-spacing:.04em;margin-bottom:7px}.rte-specialty__card p{margin:5px 0}.rte-specialty__card dl{display:grid;grid-template-columns:110px 1fr;gap:4px 10px;margin:9px 0 0}.rte-specialty__card dt{font-weight:650}.rte-specialty__card dd{margin:0;color:#405a60}.rte-specialty details{margin-top:9px;border-top:1px solid #e1edef;padding-top:7px}.rte-specialty summary{cursor:pointer;color:#145f70;font-weight:650}.rte-specialty__section{margin-top:24px}.rte-specialty__section h2{font-size:20px;margin:0 0 9px}.rte-specialty__sources{display:grid;gap:7px}.rte-specialty__source{border-left:3px solid #83b9c0;padding:7px 10px;background:#f8fbfc}.rte-specialty__notice{border:1px solid #d5e6e9;background:#f8fbfc;border-radius:8px;padding:10px 12px;color:#435b60;margin:14px 0}.rte-specialty__links{display:flex;flex-wrap:wrap;gap:8px}.rte-specialty__links a{display:inline-flex;border:1px solid var(--line);border-radius:7px;padding:7px 9px;text-decoration:none;background:#fff}.rte-specialty__links a:hover,.rte-specialty__links a:focus{background:var(--soft)}
@media(max-width:720px){.rte-specialty__head{display:block}.rte-specialty__badge{display:inline-block;margin-top:8px}.rte-specialty__intro,.rte-specialty__grid{grid-template-columns:1fr}.rte-specialty__card dl{grid-template-columns:1fr}.rte-specialty__card dd{margin-bottom:4px}}
@media(prefers-reduced-motion:reduce){.rte-specialty *{scroll-behavior:auto!important}}
.rte-safety{--danger:#9c2d2d;--amber:#8b6518;--blue:#155d72}.rte-safety__warning{border-left:4px solid var(--danger)}
.rte-safety__panel{border:1px solid #b8d4da;border-radius:12px;background:#f8fcfd;padding:16px;margin:18px 0}.rte-safety__panelhead{display:flex;justify-content:space-between;gap:16px;align-items:flex-start}.rte-safety__panelhead h2{margin:0}.rte-safety__panelhead p{margin:.3rem 0 0;color:#536b75}.rte-safety__region{font-size:12px;font-weight:650}.rte-safety__region select{display:block;margin-top:4px;padding:7px;border:1px solid #b8cbd0;border-radius:6px;background:white}
.rte-safety__druggrid{display:grid;grid-template-columns:repeat(auto-fit,minmax(190px,1fr));gap:8px;margin:14px 0}.rte-safety__drug{display:flex;gap:8px;align-items:flex-start;border:1px solid #d5e3e6;border-radius:8px;background:#fff;padding:9px;cursor:pointer}.rte-safety__drug:has(input:checked){border-color:#287685;background:#eef8fa}.rte-safety__drug small{display:block;color:#687e86;margin-top:2px}.rte-safety__analysis{border-top:1px solid #dce8eb;padding-top:12px}.rte-safety__analysis h3{font-size:15px;margin:12px 0 6px}.rte-safety__analysis ul{margin:6px 0 10px 20px}.rte-safety__signal{padding:8px 10px;border-radius:7px;margin:6px 0;background:#fff;border:1px solid #d8e5e8}.rte-safety__signal strong{display:block}
.rte-safety__tabs{display:flex;gap:6px;flex-wrap:wrap;margin:18px 0}.rte-safety__tabs button{border:1px solid #bfd2d7;background:#fff;border-radius:999px;padding:8px 12px;cursor:pointer}.rte-safety__tabs button.is-active{background:#1d6572;color:#fff;border-color:#1d6572}.rte-safety__gate{border-left:4px solid #7199a2;padding:8px 10px;margin:8px 0;background:#f9fbfc}.rte-safety__gate--red{border-color:#a33131;background:#fff7f7}.rte-safety__gate--amber{border-color:#a5761d;background:#fffbf2}.rte-safety__gate p{margin:4px 0 0}.rte-safety__profile h3{font-size:13px;margin:12px 0 4px}.rte-safety__monitor>div{padding:8px 0;border-bottom:1px solid #e3ecee}.rte-safety__monitor span,.rte-safety__monitor small{display:block}.rte-safety__monitor small{color:#677d85;margin-top:2px}.rte-safety__emergency{border-left:4px solid #a33131;padding:8px 10px;margin:8px 0;background:#fff7f7}.rte-safety__emergency ol,.rte-safety__emergencyhero ol{padding-left:22px}.rte-safety__emergencyhero{border:2px solid #a33131;border-radius:12px;padding:14px;background:#fff7f7;margin-bottom:14px}.rte-safety__emergencyhero>strong{font-size:17px}.rte-safety__view[hidden]{display:none!important}
@media(max-width:640px){.rte-safety__panelhead{display:block}.rte-safety__region{display:block;margin-top:10px}.rte-safety__druggrid{grid-template-columns:1fr 1fr}.rte-safety__drug{font-size:12px}}
.rte-safety__ready{border:1px solid #bdd6db;border-radius:12px;background:linear-gradient(180deg,#fff,#f4fafb);padding:14px;margin-bottom:14px}.rte-safety__ready h2,.rte-safety__ctcae-head h2,.rte-safety__doc h2{margin:0 0 4px;font-size:20px}.rte-safety__ready p,.rte-safety__ctcae-head p,.rte-safety__doc p{margin:4px 0 10px;color:#536b75}.rte-safety__kit{display:flex;flex-wrap:wrap;gap:6px}.rte-safety__kit span{border:1px solid #c7dde1;background:#fff;border-radius:999px;padding:5px 8px;font-size:12px}.rte-safety__contrast{border-left:4px solid #759aa2}.rte-safety__contrast--red{border-left-color:#a33131}.rte-safety__contrast--amber{border-left-color:#a5761d}.rte-safety__contrast ol{padding-left:20px}.rte-safety__sourcehint{font-size:11px;color:#6b7f85;border-top:1px solid #e4edef;padding-top:7px;margin-top:9px!important}.rte-safety__ctcae-head{display:flex;justify-content:space-between;gap:18px;align-items:flex-start;margin-bottom:14px}.rte-safety__ctcae-badge{min-width:210px;border:1px solid #c6dce0;border-radius:9px;background:#fff;padding:10px;font-size:12px}.rte-safety__ctcae-badge strong,.rte-safety__ctcae-badge span,.rte-safety__ctcae-badge a{display:block}.rte-safety__ctcae-badge span{color:#677d85;margin:2px 0 5px}.rte-safety__visualgrid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px}.rte-safety__visualcard{margin:0;border:1px solid #cbdfe2;border-radius:10px;background:#fff;overflow:hidden}.rte-safety__visualimage{display:block;aspect-ratio:4/3;background:#edf3f4;overflow:hidden}.rte-safety__visualimage img{width:100%;height:100%;object-fit:cover;display:block}.rte-safety__visualcard figcaption{padding:10px}.rte-safety__visualcard figcaption>strong,.rte-safety__visualcard figcaption>span,.rte-safety__visualcard figcaption>small{display:block}.rte-safety__visualcard figcaption>span{font-size:11px;text-transform:uppercase;letter-spacing:.04em;color:#1d7682;margin-top:2px}.rte-safety__visualcard figcaption p{margin:6px 0;color:#4e676e;font-size:13px}.rte-safety__visualcard figcaption small{color:#6b7f85}.rte-safety__sjsten{border:2px solid #9c2d2d;background:#fff6f6;border-radius:10px;padding:12px 14px;margin:16px 0}.rte-safety__sjsten strong{color:#8a2222}.rte-safety__sjsten p{margin:5px 0 0}.rte-safety__doc{border:1px solid #bdd6db;border-radius:12px;padding:14px;background:#f8fcfd;margin-top:18px}.rte-safety__docgrid{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:9px}.rte-safety__docgrid label{font-size:12px;font-weight:650}.rte-safety__docgrid input,.rte-safety__docgrid select{display:block;width:100%;margin-top:4px;border:1px solid #b8cbd0;border-radius:6px;background:#fff;padding:8px;font:inherit;font-weight:400}.rte-safety__copy{margin-top:10px;border:1px solid #1d6572;border-radius:7px;background:#1d6572;color:#fff;padding:8px 11px;cursor:pointer}.rte-safety__docout{width:100%;min-height:90px;margin-top:10px;border:1px solid #c4d7db;border-radius:7px;background:#fff;padding:9px;font:13px/1.45 ui-monospace,SFMono-Regular,Consolas,monospace;resize:vertical}
@media(max-width:900px){.rte-safety__visualgrid{grid-template-columns:repeat(2,minmax(0,1fr))}.rte-safety__docgrid{grid-template-columns:repeat(2,minmax(0,1fr))}}
@media(max-width:640px){.rte-safety__ctcae-head{display:block}.rte-safety__ctcae-badge{margin-top:8px}.rte-safety__visualgrid,.rte-safety__docgrid{grid-template-columns:1fr}.rte-safety__tabs{overflow-x:auto;flex-wrap:nowrap;padding-bottom:3px}.rte-safety__tabs button{white-space:nowrap}}